Sera Toshihiro, Uesugi Kentaro, Yagi Naoto
Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), Hyogo, Japan.
J Physiol Anthropol Appl Human Sci. 2005 Jul;24(4):465-8. doi: 10.2114/jpa.24.465.
Localized morphometric deformations of small airways and alveoli during respiration have many biomedical and physiological implications. We developed fast synchrotron radiation CT system to visualize the small airways and alveoli of an intact mouse lung without fixation and dehydration, and analyzed their localized morphometric deformations between functional residual capacity (FRC) and total lung capacity (TLC). In the diameter behavior, the averaged and range values were significantly larger for smaller airways (68.8%, range: 0.36-0.89) than larger airways (45.2%, range: 0.40-0.57). These results indicated that the airway did not deformed in same manner and that these morphological differences characterized the heterogeneous lung function.
呼吸过程中小气道和肺泡的局部形态计量学变形具有许多生物医学和生理学意义。我们开发了快速同步辐射CT系统，以在不进行固定和脱水的情况下可视化完整小鼠肺的小气道和肺泡，并分析了它们在功能残气量（FRC）和肺总量（TLC）之间的局部形态计量学变形。在直径变化方面，较小气道（平均变化率68.8%，范围：0.36 - 0.89）的平均值和变化范围值显著大于较大气道（平均变化率45.2%，范围：0.40 - 0.57）。这些结果表明气道并非以相同方式变形，并且这些形态学差异表征了肺功能的异质性。
