[间隙连接——促进细胞间通讯的主要结构]

[Gap junctions--major structures promoting intercellular communication].

作者信息

Shubich M G, Ermoshenko B G, Perov Iu M, Dorofeeva I V

出版信息

Morfologiia. 2005;127(1):65-71.

Abstract

Gap junctions provide humoral and electric communication between the cells, thus contributing to their morpho-functional cooperation. Gap junction is formed by multiple intercellular channels, each of them being made by two closed hemichannels--connexons, that are oligomeric transmembrane proteins built by 6 subunits, belonging to connexin family. Permeability and electric conductivity of gap junction channels is determined by molecular peculiarities of connexins, their capacity for phosphorilation and by some extra- and intracellular factors. According to the current data, gap junctions in both cell cultures and tissues are dynamic structures with a short half-life period. Main mechanisms responsible for gap junction assembly and destruction have been discovered. These mechanisms were shown to depend upon peculiarities of differential genome activity and to be controlled by extra- and intracellular factors. The data on the gap junctions in the nervous system, heart and epidermis are presented.

摘要

间隙连接为细胞间提供体液和电通讯，从而促进它们在形态功能上的协作。间隙连接由多个细胞间通道形成，每个通道由两个封闭的半通道——连接子构成，连接子是由6个亚基组成的寡聚跨膜蛋白，属于连接蛋白家族。间隙连接通道的通透性和导电性由连接蛋白的分子特性、其磷酸化能力以及一些细胞外和细胞内因素决定。根据目前的数据，细胞培养物和组织中的间隙连接都是半衰期较短的动态结构。已经发现了负责间隙连接组装和破坏的主要机制。这些机制显示取决于差异基因组活性的特性，并受细胞外和细胞内因素控制。文中还介绍了神经系统、心脏和表皮中间隙连接的相关数据。