Metherate Raju, Kaur Simranjit, Kawai Hideki, Lazar Ronit, Liang Kevin, Rose Heather J
Department of Neurobiology and Behavior, University of California, Irvine, 2205 McGaugh Hall, Irvine, CA 92697-4550, United States.
Hear Res. 2005 Aug;206(1-2):146-58. doi: 10.1016/j.heares.2005.01.014.
Auditory cortex contributes to the processing and perception of spectrotemporally complex stimuli. However, the mechanisms by which this is accomplished are not well understood. In this review, we examine evidence that single cortical neurons receive input covering much of the audible spectrum. We then propose an anatomical framework by which spectral information converges on single neurons in primary auditory cortex, via a combination of thalamocortical and intracortical "horizontal" pathways. By its nature, the framework confers sensitivity to specific, spectrotemporally complex stimuli. Finally, to address how spectral integration can be regulated, we show how one neuromodulator, acetylcholine, could act within the hypothesized framework to alter integration in single neurons. The results of these studies promote a cellular understanding of information processing in auditory cortex.
听觉皮层有助于对频谱-时间复杂刺激进行处理和感知。然而，实现这一过程的机制尚不清楚。在本综述中，我们研究了单个皮层神经元接收覆盖大部分可听频谱输入的证据。然后，我们提出了一个解剖学框架，通过丘脑皮质和皮质内“水平”通路的组合，使频谱信息汇聚到初级听觉皮层的单个神经元上。从本质上讲，该框架赋予了对特定频谱-时间复杂刺激的敏感性。最后，为了解决频谱整合如何受到调节的问题，我们展示了一种神经调质乙酰胆碱如何在假设的框架内发挥作用，以改变单个神经元的整合。这些研究结果促进了对听觉皮层信息处理的细胞层面理解。
