Leite Carla L A, Redins Carlos A, Vasquez Elisardo C, Meyrelles Silvana S
Physiological Sciences Graduate Program, Biomedical Center, Federal University of Espirito Santo, Vitoria, ES, Brazil.
Clin Exp Hypertens. 2005 Aug;27(6):523-31. doi: 10.1081/CEH-200067688.
Studies show that systemic diseases such as diabetes, hyperthyroidism, osteoporosis, and dyslipidemia may influence periodontal inflammation. However, few studies relate the influence of arterial hypertension on periodontitis. The present study was undertaken to assess the severity of the experimental ligature-induced periodontitis in an experimental model of genetic arterial hypertension. The experimental periodontitis model was induced in 6 spontaneously hypertensive rats (SHR) and 6 Wistar normotensive rats (NT) by cotton ligature, which was placed subgingivaly around the neck of the first left inferior molar tooth. In the same animal, the first right molar tooth was sham-ligated and used as a control. After 7 days, the mean arterial pressure (MAP) and heart rate (HR) were recorded in conscious animals. As expected, MAP was significantly higher in SHR (151 +/- 6 mmHg) than in NT (105 +/- 3 mmHg), without significant differences in HR. The histopathologic examination of the periodontal structure showed alveolar integrity and lack of neutrophils and osteoclasts in the control side of both SHR and NT. In contrast, examination of the ligated side in all animals showed collagen degradation in the alveolar process from a moderate (50%) to severe (50%) level in SHR and mild in NT (100%). These data show that experimental periodontitis, characterized by the spreading of the inflammatory process from the gingiva deep into periodontium tissues, is greatly exacerbated in SHR.
研究表明，糖尿病、甲状腺功能亢进、骨质疏松症和血脂异常等全身性疾病可能会影响牙周炎症。然而，很少有研究探讨动脉高血压对牙周炎的影响。本研究旨在评估遗传性动脉高血压实验模型中实验性结扎诱导的牙周炎的严重程度。通过在6只自发性高血压大鼠（SHR）和6只Wistar正常血压大鼠（NT）的左下第一磨牙颈部龈下放置棉线结扎，诱导建立实验性牙周炎模型。在同一只动物中，右侧第一磨牙进行假结扎作为对照。7天后，记录清醒动物的平均动脉压（MAP）和心率（HR）。正如预期的那样，SHR的MAP（151±6 mmHg）显著高于NT（105±3 mmHg），而HR无显著差异。牙周结构的组织病理学检查显示，SHR和NT的对照侧牙槽骨完整，无中性粒细胞和破骨细胞。相比之下，所有动物结扎侧的检查显示，SHR的牙槽突胶原降解程度从中度（50%）到重度（50%），而NT为轻度（100%）。这些数据表明，以炎症过程从牙龈扩散到牙周组织为特征的实验性牙周炎在SHR中会大大加重。
