Takahashi T, Koyama N
Department of Anesthesiology, Medical College of Shiga, Otsu.
Masui. 1992 May;41(5):751-65.
Effects of intravenous administration of tizanidine upon spinal reflexes were studied in cats anesthetized with urethane-chloralose. Both extensor and flexor monosynaptic reflexes and polysynaptic flexor reflex were inhibited by intravenous administration of tizanidine in a dose of 10-50 micrograms.kg-1. The inhibition was dose-dependent. After strychnine administration, polysynaptic flexor reflex was augmented, but the inhibition by tizanidine administration was unaffected. In spinal cats, inhibitory effect of tizanidine upon monosynaptic reflex was weaker than in intact cats. Viscero-intercostal reflex elicited by electrical stimulation of A delta afferent fibers in the greater splanchnic nerve was also inhibited by intravenous tizanidine (25 micrograms.kg-1). The degree of inhibition decreased in parallel with increase in the intensity of stimulus applied to the greater splanchnic nerve.
在使用乌拉坦-氯醛糖麻醉的猫身上研究了静脉注射替扎尼定对脊髓反射的影响。静脉注射剂量为10-50微克·千克-1的替扎尼定可抑制伸肌和屈肌单突触反射以及多突触屈肌反射。这种抑制呈剂量依赖性。注射士的宁后，多突触屈肌反射增强，但替扎尼定注射所致的抑制不受影响。在脊髓猫中，替扎尼定对单突触反射的抑制作用比在完整猫中弱。静脉注射替扎尼定（25微克·千克-1）也可抑制由电刺激内脏大神经中的Aδ传入纤维所引发的内脏肋间反射。抑制程度随着施加于内脏大神经的刺激强度增加而平行降低。
