García-Bujalance S, de Guevara C Ladrón, González-García J, Arribas J R, Gutiérrez A
Department of Microbiology and Parasitology, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
J Clin Microbiol. 2005 Aug;43(8):4186-8. doi: 10.1128/JCM.43.8.4186-4188.2005.
The purpose of this study was to compare a line probe assay (LiPA) with sequence analysis for the detection of mutations conferring resistance to nucleoside and non-nucleoside inhibitors in human immunodeficiency reverse transcriptase and protease inhibitors. The limitations for interpreting LiPA make it unacceptable for routine clinical practice.
本研究的目的是比较线性探针分析(LiPA)与序列分析,以检测人类免疫缺陷病毒逆转录酶和蛋白酶抑制剂中赋予对核苷类和非核苷类抑制剂耐药性的突变。LiPA在解释方面的局限性使其不适合常规临床实践。