Gavrilov O K, Novozhenova T V, Lekokhmakher S S, Dobashina A N, Fedoseev A N, Miagkova M A
Klin Med (Mosk). 1992 Jan;70(1):23-6.
Coagulation in angina pectoris has been analyzed in a normal and elevated level of natural antibodies (nAb) to thrombin. A correlation was found between the level of nAb to thrombin and hemostatic shifts. The correlation of a nAb rise was attempted by means of plasmapheresis (PA) or plasmosorption (PS), altering coagulation potential. PA and PS produced more pronounced anticoagulative effects in patients with a normal baseline level of nAb to thrombin. When the latter levels tended to reduction from initially high, hemostatic processes improved. It is concluded that nAb to thrombin levels have prognostic potential as an indicator of coagulation activity and efficacy of anticoagulant therapy in extracorporeal interventions.
对处于正常水平和升高水平的抗凝血酶天然抗体（nAb）状态下的心绞痛凝血情况进行了分析。发现抗凝血酶nAb水平与止血变化之间存在相关性。尝试通过血浆置换（PA）或血浆吸附（PS）来提高nAb水平，从而改变凝血潜能。PA和PS在抗凝血酶nAb基线水平正常的患者中产生了更显著的抗凝作用。当后者水平从最初的高水平趋于降低时，止血过程得到改善。得出的结论是，抗凝血酶nAb水平作为体外干预中凝血活性和抗凝治疗效果的指标具有预后潜力。
