Noguchi Sumio, Takase Kazunori, Yoshida Minoru, Yumura Yasushi, Yamashita Yuzo, Oogo Yoshiharu, Miyoshi Yasuhide
Department of Urology, Yokosuka Kyosai Hospital.
Nihon Hinyokika Gakkai Zasshi. 2005 Jul;96(5):548-53. doi: 10.5980/jpnjurol1989.96.548.
To know the survival and prognostic factors of the patients who received radical cystectomy with or without neoadjuvant cisplatin-based chemotherapy.
Between 1977 and 2001, 201 patients underwent radical cystectomy at Yokohama City University and Yokosuka Kyosai Hospital whose tumor were clinically diagnosed as locally invasive bladder cancer (T2-4NxM0). Survival rates and 9 prognostic factors (Age, Size, Multiplicity, Type, Grade, p-stage, n,neoadjuvant chemotherapy, adjuvant chemotherapy) were analysed by Kaplan-Meier methods and Cox-proportional hazard model.
The independent prognostic factors of these patients were size, multiplicity, type, grade, p-stage, n, neoadjuvant by univariate analysis. Of these 7 factors, n, neoadjuvant, p-stage and size are significant by multivariate analysis. Survival of the patients who received neoadjuvant cisplatin-based chemotherapy followed cystectomy is better than cystectomy only group by Kaplan-Meier method.
From these rusults, neoadjuvant cisplatin-based chemotherapy play some role for survival of the patients with invasive bladder cancer.
了解接受根治性膀胱切除术加或不加以顺铂为基础的新辅助化疗患者的生存情况及预后因素。
1977年至2001年间，201例患者在横滨市立大学和横须贺共济医院接受了根治性膀胱切除术，其肿瘤临床诊断为局部浸润性膀胱癌（T2-4NxM0）。采用Kaplan-Meier法和Cox比例风险模型分析生存率及9个预后因素（年龄、大小、多发性、类型、分级、p分期、淋巴结转移情况、新辅助化疗、辅助化疗）。
单因素分析显示这些患者的独立预后因素为大小、多发性、类型、分级、p分期、淋巴结转移情况、新辅助化疗。多因素分析显示，在这7个因素中，淋巴结转移情况、新辅助化疗、p分期和大小具有显著性。Kaplan-Meier法显示，接受以顺铂为基础的新辅助化疗后再行膀胱切除术患者的生存率高于单纯膀胱切除术组。
从这些结果来看，以顺铂为基础的新辅助化疗对浸润性膀胱癌患者的生存有一定作用。
