Seleye-Fubara D, Nwosu S O, Yellowe B E
Department of Anatomical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.
Niger J Med. 2005 Apr-Jun;14(2):188-94. doi: 10.4314/njm.v14i2.37179.
Soft tissue sarcomas are rare tumours in this environment. Recently, an upsurge in frequency was noticed that called for attention. The aim of this study is to study soft tissue sarcomas based on age, sex of patients, tumour sites and histologic types.
A 14 year retrospective study in University of Port Harcourt Teaching Hospital (UPTH) Port Harcourt. Histological slides previously processed and stained with hematoxylin and eosin stains (H & E) were reviewed and re-evaluated. Special stains were also used for proper diagnosis of some tumours. The tumours were classified based on World Health Organization (WHO) classification of soft tissue tumours.
Only 66 soft tissue sarcomas were used for this study which accounted for 2.8% of the total malignancies diagnosed during the period under review. The youngest was a 3 year old girl while the eldest was a 76 year old female. A total of 38 and 28 tumours were diagnosed in males and females respectively, giving a sex ratio of 1.4:1. Rhabdomyosarcoma was most frequent (39.4%) while the least was leiomyosarcoma (1.5%). These tumours are more frequent in the under 20 years (22.7%) and least in 70 years and above (7.6%). The lower limb was most affected (36.4%) while the least was the retroperitoneum (6.1%). The commonest predilection sites vary with different classes of these group malignancies.
Soft tissue malignancies are globally uncommon but they constituted an integral part of malignant tumours causing serious morbidity and mortality in this environment. The recent upsurge noticed necessitated the need for regional studies in Nigeria in order to come up with a national epidemiologic data of these malignancies.
软组织肉瘤在这种环境中是罕见肿瘤。最近，其发病率出现上升，值得关注。本研究旨在基于患者的年龄、性别、肿瘤部位和组织学类型对软组织肉瘤进行研究。
在哈科特港大学教学医院（UPTH）进行了一项为期14年的回顾性研究。对先前用苏木精和伊红染色（H&E）处理过的组织学切片进行复查和重新评估。还使用特殊染色对一些肿瘤进行准确诊断。这些肿瘤根据世界卫生组织（WHO）软组织肿瘤分类进行分类。
本研究仅纳入66例软组织肉瘤，占所审查期间诊断出的所有恶性肿瘤的2.8%。最年轻的是一名3岁女孩，最年长的是一名76岁女性。男性和女性分别诊断出38例和28例肿瘤，性别比为1.4:1。横纹肌肉瘤最为常见（39.4%），而平滑肌肉瘤最少见（1.5%）。这些肿瘤在20岁以下人群中更为常见（22.7%），在70岁及以上人群中最少见（7.6%）。下肢受影响最严重（36.4%），而后腹膜最少见（6.1%）。这些肿瘤的常见偏好部位因这些恶性肿瘤的不同类别而异。
软组织恶性肿瘤在全球范围内并不常见，但它们是恶性肿瘤的一个组成部分，在这种环境中会导致严重的发病率和死亡率。最近注意到的发病率上升使得尼日利亚有必要进行区域研究，以便得出这些恶性肿瘤的全国流行病学数据。
