Ellis Jeffrey J, Eagle Kim A, Kline-Rogers Eva M, Erickson Steven R
Lincoln Surgical Hospital, Department of Pharmacy, Lincoln, NE, USA.
Curr Med Res Opin. 2005 Aug;21(8):1209-16. doi: 10.1185/030079905X56349.
To analyze the construct validity of the EQ-5D in patients with acute coronary syndromes (ACS).
All ACS-diagnosed patients discharged from a university-affiliated hospital during a 3-year period were mailed a questionnaire that included the EQ-5D and the SF-8. The EQ-5D includes a visual analogue scale (EQ VAS) to measure self-reported current health-status (0-100) and a five-item descriptive system measuring mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Also included were disease severity measures [Duke Activity Status Index (DASI), cardiac symptom count (SC), patient-perceived cardiac disease severity], comorbidity measures (Charlson comorbidity index, total medication count), and other demographic and disease-related items.
Of 1217 patients, 490 (40.3%) responded. Patients averaged 65.2 (SD 11.3) years of age; 71.0% male; 91.9% Caucasian; 64.3% history of MI. Only 0.2%-0.4% of EQ-5D items and 8% of the EQ VAS were left unanswered by respondents. The nine most common health states were identified based on the five EQ-5D item scores. Levels of responses to EQ-5D items and the EQ VAS score were significantly better for patients with very mild/mild perceived disease severity compared to severe/very severe, for patients with lower comorbidity, for patients with lower symptom responses, and for patients with a higher cardiac-related functioning. EQ VAS score and SF-8 subscale score correlation coefficients ranged from 0.527 to 0.798 (all p < 0.0001). Significant differences were observed between the response level of individual EQ-5D items and scores of comparable SF-8 subscales.
This study demonstrated the construct validity of the EQ-5D in a population-based sample of patients with a history of ACS.
分析急性冠状动脉综合征（ACS）患者中EQ-5D量表的结构效度。
向一所大学附属医院在3年期间出院的所有确诊为ACS的患者邮寄一份问卷，其中包括EQ-5D量表和SF-8量表。EQ-5D量表包括一个视觉模拟量表（EQ VAS），用于测量自我报告的当前健康状况（0至100），以及一个五项描述系统，用于测量行动能力、自我护理、日常活动、疼痛/不适和焦虑/抑郁。还包括疾病严重程度指标[杜克活动状态指数（DASI）、心脏症状计数（SC）、患者感知的心脏病严重程度]、合并症指标（查尔森合并症指数、总用药数）以及其他人口统计学和疾病相关项目。
1217名患者中，490名（40.3%）做出了回应。患者平均年龄为65.2岁（标准差11.3）；男性占71.0%；白种人占91.9%；有心肌梗死病史的占64.3%。受访者对EQ-5D量表项目的未回答率仅为0.2% - 0.4%，对EQ VAS的未回答率为8%。根据EQ-5D量表的五项得分确定了九种最常见的健康状态。与病情严重/非常严重的患者相比，自我感知疾病严重程度为非常轻微/轻微的患者、合并症较少的患者、症状反应较少的患者以及心脏相关功能较高的患者，对EQ-5D量表项目的回答水平和EQ VAS得分明显更好。EQ VAS得分与SF-8量表各子量表得分的相关系数在0.527至0.798之间（所有p < 0.0001）。在EQ-5D量表单个项目的回答水平与SF-8量表可比子量表得分之间观察到显著差异。
本研究证明了EQ-5D量表在有ACS病史的人群样本中的结构效度。
