原发性中枢神经系统淋巴瘤的治疗。

Treatment of primary central nervous system lymphoma.

作者信息

Shah Gaurav D, DeAngelis Lisa M

机构信息

Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

出版信息

Hematol Oncol Clin North Am. 2005 Aug;19(4):611-27, v. doi: 10.1016/j.hoc.2005.05.002.

DOI:10.1016/j.hoc.2005.05.002

PMID:16083826

Abstract

Primary central nervous system lymphoma (PCNSL) describes a malignant non-Hodgkin's lymphoma (NHL) whose sole site of involvement is the central nervous system (CNS). The diagnosis of PCNSL must be differentiated from systemic NHL with metastasis to the CNS, which usually occurs late in the course of systemic disease. PCNSL accounts for approximately 4% to 7% of primary brain tumors, and its incidence has been increasing since the mid-1970s. Compared with other more common malignant primary brain tumors, PCNSL tends to be more amenable to radiotherapeutic and chemotherapeutic intervention. In this article, the authors review the standard treatment for upfront and recurrent PCNSL.

摘要

原发性中枢神经系统淋巴瘤（PCNSL）是指一种恶性非霍奇金淋巴瘤（NHL），其唯一受累部位是中枢神经系统（CNS）。PCNSL的诊断必须与伴有CNS转移的系统性NHL相鉴别，后者通常发生在系统性疾病病程的晚期。PCNSL约占原发性脑肿瘤的4%至7%，自20世纪70年代中期以来其发病率一直在上升。与其他更常见的恶性原发性脑肿瘤相比，PCNSL往往更适合接受放射治疗和化学治疗干预。在本文中，作者回顾了初治和复发性PCNSL的标准治疗方法。