Jensen M K, d'Amore F A, Jensen M K, Christensen B E, Thorling K, Pedersen M, Johansen P, Boesen A M, Andersen E
Aalborg Sygehus Syd, medicinsk-haematologisk afdeling og onkologisk afdeling.
Ugeskr Laeger. 1996 Jul 29;158(31):4406-12.
In a Danish population-based non-Hodgkin's lymphoma (NHL) registry (LYFO) representing a population of 2.7 million all new cases of NHL were registered from 1st January 1983 to 31st May 1994. Incidence data of primary malignant tumours of the brain and central nervous system in western Denmark for the period 1971-1990 have been obtained from the Danish Cancer Registry. During the approximate 11-year period 3124 new cases of NHL were registered. Of these, 1152 (37%) were extranodal and 48 were non-AIDS related primary central nervous system lymphomas (PCNSL) accounting for 4.2% of extranodal NHL and 1.5% of all NHL, respectively. The average annual incidence rate of non-AIDS related PCNSL during the period was 1.56 cases per million population (age range: 15-85 yrs, median: 62 yrs, M/F ratio: 1). In a 23-year period there was no trend towards an increasing incidence of non-AIDS related PCNSL in a well-defined population. PCNSL accounted for 1.7% of all primary malignant brain tumours. Incidence of primary malignant brain tumours was stable, except for age ranges over 70 years. Histologically, 85% were high grade, centroblastic diffuse (60%) and immunoblastic lymphoma (13%) (Kiel classification). No T-cell lymphomas were detected. Treatment included surgical resection, whole brain irradiation (WBRT) and chemotherapy. Median survival for those receiving either WBRT or WBRT and chemotherapy was eight months and 20 months, respectively (p = 0.78). Overall survival was 53%, 38% and 26% at one, two and five years. Cox-regression analysis identified only one factor having independent impact on survival in performance score > or = 2 (PCNSL p < 0.001, RR = 5.8).
在一个基于丹麦人群的非霍奇金淋巴瘤（NHL）登记处（LYFO），该登记处涵盖270万人口，从1983年1月1日至1994年5月31日登记了所有新的NHL病例。丹麦癌症登记处提供了1971 - 1990年丹麦西部脑和中枢神经系统原发性恶性肿瘤的发病率数据。在大约11年的时间里，登记了3124例新的NHL病例。其中，1152例（37%）为结外病例，48例为非艾滋病相关的原发性中枢神经系统淋巴瘤（PCNSL），分别占结外NHL的4.2%和所有NHL的1.5%。在此期间，非艾滋病相关PCNSL的年均发病率为每百万人口1.56例（年龄范围：15 - 85岁，中位数：62岁，男/女比例：1）。在23年的时间里，在一个明确界定的人群中，非艾滋病相关PCNSL的发病率没有上升趋势。PCNSL占所有原发性恶性脑肿瘤的1.7%。原发性恶性脑肿瘤的发病率稳定，但70岁以上年龄组除外。组织学上，85%为高级别，中心母细胞弥漫性（60%）和免疫母细胞淋巴瘤（13%）（基尔分类）。未检测到T细胞淋巴瘤。治疗包括手术切除、全脑照射（WBRT）和化疗。接受WBRT或WBRT加化疗的患者的中位生存期分别为8个月和20个月（p = 0.78）。1年、2年和5年的总生存率分别为53%、38%和26%。Cox回归分析仅确定了一个对表现评分>或 = 2时的生存有独立影响的因素（PCNSL p < 0.001，RR = 5.8）。
