继发性中枢神经系统淋巴瘤：危险因素与预防

Secondary central nervous system lymphoma: risk factors and prophylaxis.

作者信息

Montoto Silvia, Lister T Andrew

机构信息

Medical Oncology Department, St. Bartholomew's Hospital, Little Britain 45, London EC1A 7BE, UK.

出版信息

Hematol Oncol Clin North Am. 2005 Aug;19(4):751-63, viii. doi: 10.1016/j.hoc.2005.05.008.

DOI:10.1016/j.hoc.2005.05.008

PMID:16083835

Abstract

Patients diagnosed with diffuse large-cell lymphoma, peripheral T-cell non-Hodgkin's lymphoma or mantle cell lymphoma (either with a high serum lactate dehydrogenase level), more than one extranodal site, or who are a high risk according to the international Prognostic Index, should receive central nervous system prophylaxis either with intrathecal or high-dose systemic chemotherapy. The appropriateness of the same prophylaxis at relapse needs to be addressed in further studies.

摘要

被诊断为弥漫性大细胞淋巴瘤、外周T细胞非霍奇金淋巴瘤或套细胞淋巴瘤（血清乳酸脱氢酶水平高者）、有一个以上结外部位或根据国际预后指数属于高危的患者，应接受鞘内注射或大剂量全身化疗进行中枢神经系统预防。复发时同样预防措施的适宜性有待进一步研究探讨。