糖皮质激素受体基因多态性对糖皮质激素敏感性的影响在多发性硬化症患者中被高估。
The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis.
作者信息
van Winsen Lisa L M, Hooper-van Veen Tineke, van Rossum Elisabeth F C, Polman Chris H, van den Berg Timo K, Koper Jan W, Uitdehaag Bernard M J
机构信息
Dept. of Neurology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
出版信息
J Neuroimmunol. 2005 Oct;167(1-2):150-6. doi: 10.1016/j.jneuroim.2005.06.010.
Glucocorticoid (GC) sensitivity varies considerably in healthy controls as well as in patients with chronic inflammatory diseases like multiple sclerosis (MS). We investigated whether polymorphisms in the glucocorticoid receptor (N363S, ER22/23EK, and the BclI) were responsible for altered GC sensitivity. In healthy controls we found an association between the N363S allele of the GR and a reduced peripheral GC sensitivity. In MS patients neither the variant N363S, the BclI RFLP nor the ER22/23EK allele were found to be associated with GC sensitivity. GC sensitivity is probably in part genetically influenced in healthy controls, but in MS patients other factors seem to have more impact on GC sensitivity.
糖皮质激素（GC）敏感性在健康对照人群以及患有慢性炎症性疾病（如多发性硬化症，MS）的患者中存在很大差异。我们研究了糖皮质激素受体的多态性（N363S、ER22/23EK和BclI）是否与GC敏感性改变有关。在健康对照人群中，我们发现GR的N363S等位基因与外周GC敏感性降低之间存在关联。在MS患者中，未发现变异的N363S、BclI限制性片段长度多态性（RFLP）或ER22/23EK等位基因与GC敏感性有关。GC敏感性在健康对照人群中可能部分受遗传影响，但在MS患者中，其他因素似乎对GC敏感性有更大影响。
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