Ergun Suleyman, Tilki Derya, Oliveira-Ferrer Leticia, Schuch Gunter, Kilic Nerbil
Center of Experimental Medicine, Institute of Anatomy I, University Hospital Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.
Cancer Lett. 2006 Jul 18;238(2):180-7. doi: 10.1016/j.canlet.2005.06.033. Epub 2005 Aug 9.
This mini review highlights the role of vascular stabilization which is apparently mediated by factors belonging to both the pro- and anti-angiogenic group. Knowingly angiopoietin-1 has pro-angiogenic properties while endostatin acts anti-angiogenic. But both factors suppress tumor growth in experimental tumor models. The crossing points of mechanisms of their action are the parameters vascular stabilization and vascular permeability, which are of high importance not only for tumor vascularization, but also for tissue vascularization in general. Both angiopoietin-1 and endostatin reduce the vascular permeability, but promote vascular stabilization. Vascular stabilization is significantly increased under experimental treatment of tumors with angiogenesis inhibitors such as endostatin. It inhibits tumor growth and probably tumor metastasis. The understanding of temporal and spatial sequences of vascular stabilization is an important challenge for scientists working on tumor vascularization and anti-angiogenic tumor therapy.
本综述强调了血管稳定的作用，这显然是由促血管生成和抗血管生成两组因子介导的。已知血管生成素-1具有促血管生成特性，而内皮抑素具有抗血管生成作用。但在实验性肿瘤模型中，这两种因子均能抑制肿瘤生长。它们作用机制的交叉点是血管稳定和血管通透性参数，这些参数不仅对肿瘤血管生成非常重要，而且对一般组织血管生成也很重要。血管生成素-1和内皮抑素都能降低血管通透性，但促进血管稳定。在用内皮抑素等血管生成抑制剂对肿瘤进行实验性治疗时，血管稳定性显著增加。它抑制肿瘤生长，可能还抑制肿瘤转移。了解血管稳定的时空序列是从事肿瘤血管生成和抗血管生成肿瘤治疗研究的科学家面临的一项重要挑战。
