Epidemiology Branch, Laboratory of Women's Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Fertil Steril. 2011 Jan;95(1):242-6. doi: 10.1016/j.fertnstert.2010.05.011. Epub 2010 Jun 17.
To describe the short-term changes in growth of uterine leiomyomas (fibroids).
Prospective observational study.
University research center.
PATIENT(S): Premenopausal women with fibroids (18 blacks and 18 whites) recruited through a physician network and community outreach.
INTERVENTION(S): Not applicable.
MAIN OUTCOME MEASURE(S): The volumes of 101 fibroids were measured at enrollment, 3, 6, and 12 months with magnetic resonance imaging, resulting in three interval-specific growth rates. Growth spurts were defined by interval growth rates≥30% per 3 months and substantially greater than during other intervals of observation. An overall measure of short-term change in fibroid growth was calculated as the variance of the three interval-specific growth rates.
RESULT(S): Growth spurts were observed in 37 of the 101 fibroids, a prevalence nearly tenfold higher than that attributable to potential measurement error. Fibroids from the same woman did not have similar short-term growth, nor were woman-specific factors (age, race/ethnicity, parity, body mass) or the fibroid position in the uterus important. However, large fibroids (>5 cm diameter) had less short-term change than smaller fibroids.
CONCLUSION(S): Short spurts of growth are common for fibroids, suggesting that tumor biology may change rapidly.
描述子宫肌瘤（纤维瘤）生长的短期变化。
前瞻性观察性研究。
大学研究中心。
通过医生网络和社区外展招募的患有肌瘤的绝经前妇女（18 名黑人，18 名白人）。
不适用。
101 个肌瘤的体积在入组时、3 个月、6 个月和 12 个月通过磁共振成像进行测量，从而得出三个特定间隔的生长率。生长突增通过间隔生长率≥3 个月增长 30%以上且明显高于观察期间的其他间隔来定义。肌瘤生长短期变化的总体衡量标准是三个特定间隔生长率的方差。
在 101 个肌瘤中有 37 个出现生长突增，这一发生率是潜在测量误差所致发生率的近十倍。同一妇女的肌瘤没有相似的短期生长，妇女特有的因素（年龄、种族/民族、产次、体重指数）或肌瘤在子宫中的位置也不重要。然而，较大的肌瘤（直径>5 厘米）的短期变化较小。
肌瘤生长的短期突增很常见，表明肿瘤生物学可能迅速变化。
