Tiong Alice Y, Brieger David
Department of Cardiology, Concord Repatriation General Hospital, Sydney, Australia.
Am Heart J. 2005 Jul;150(1):11-8. doi: 10.1016/j.ahj.2004.12.019.
Inflammation is now recognized as being pivotal in the pathogenesis of atherosclerosis. This review highlights key concepts in our current understanding of the role of inflammation in the initiation, progression, and complication of atherosclerosis. The role of various triggers and amplifiers and the innate and adaptive immunity in the cascade of inflammatory events are also presented. Progress in our understanding of the inflammatory pathways in atherosclerosis has provided further mechanistic insight into the clinical benefits of current medical therapy and may alter our future treatment and preventive strategies.
炎症现已被认为在动脉粥样硬化的发病机制中起关键作用。本综述重点介绍了我们目前对炎症在动脉粥样硬化的起始、进展和并发症中所起作用的理解中的关键概念。还介绍了各种触发因素和放大器以及固有免疫和适应性免疫在炎症事件级联反应中的作用。我们对动脉粥样硬化炎症途径理解的进展为当前药物治疗的临床益处提供了进一步的机制性见解,并可能改变我们未来的治疗和预防策略。