伴有和不伴有左心房缺血的左心室缺血期间左心房功能的定量分析：一项实时三维超声心动图研究

Quantitative analysis of left atrial function during left ventricular ischemia with and without left atrial ischemia: a real-time 3-dimensional echocardiographic study.

作者信息

Bauer Fabrice, Jones Michael, Qin Jian Xin, Castro Peter, Asada Junko, Sitges Marta, Cardon Lisa A, Tsujino Hiroyuki, Zetts Arthur D, Panza Julio A, Thomas James D, Shiota Takahiro

机构信息

Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

出版信息

J Am Soc Echocardiogr. 2005 Aug;18(8):795-801. doi: 10.1016/j.echo.2005.01.018.

DOI:10.1016/j.echo.2005.01.018

PMID:16084330

Abstract

Left atrial (LA) systolic and diastolic function were analyzed in an animal model of acute left ventricular ischemia with LA ischemia by proximal left circumflex coronary artery occlusion or without LA ischemia by midleft anterior descending coronary artery occlusion (7 sheep in each group). LA pressures and LA volumes were simultaneously recorded using a catheter and real-time 3-dimensional echocardiography, respectively. LA stroke volume represented 63% of left ventricular stroke volume during left anterior descending coronary artery occlusion, but only 32% during left circumflex coronary artery occlusion. This animal study with 3-dimensional echocardiographic determination of absolute LA volumes demonstrated dramatic depression of LA function during proximal left circumflex coronary artery occlusion as compared with left anterior descending coronary artery occlusion.

摘要

通过近端左旋支冠状动脉闭塞建立伴有左心房缺血的急性左心室缺血动物模型，或通过左前降支冠状动脉中段闭塞建立不伴有左心房缺血的动物模型（每组7只绵羊），分析左心房（LA）的收缩和舒张功能。分别使用导管和实时三维超声心动图同时记录左心房压力和左心房容积。在左前降支冠状动脉闭塞期间，左心房每搏输出量占左心室每搏输出量的63%，但在左旋支冠状动脉闭塞期间仅占32%。这项通过三维超声心动图测定左心房绝对容积的动物研究表明，与左前降支冠状动脉闭塞相比，近端左旋支冠状动脉闭塞期间左心房功能显著降低。