Zanoli Paola, Zavatti Manuela, Rivasi Marianna, Baraldi Mario
Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Italy.
Physiol Behav. 2005 Sep 15;86(1-2):69-74. doi: 10.1016/j.physbeh.2005.06.025.
The influence of Ferula hermonis root extract on sexual behavior was studied in female rats. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate (EB) and progesterone (P) and then treated with F. hermonis extract acutely (30 and 60 mg/kg) or subchronically (1 and 10 mg/kg daily for 10 consecutive days). A significant reduction in lordosis responses was observed in rats after acute (60 mg/kg) or subchronic (1 and 10 mg/kg) administration of the plant extract. Similarly, a decrease in proceptive behaviors was exhibited by F. hermonis treated rats in comparison with EB+P controls. No difference was found in the patterns of paced mating behavior between control and treated animals. The present results demonstrate that the acute or repeated ingestion of F. hermonis specifically impairs the receptive and proceptive components of female sexual behavior. The effect could be the consequence of an antiestrogenic action of the extract in hormone-primed female rats.
研究了赫莫尼斯阿魏草根提取物对雌性大鼠性行为的影响。对用苯甲酸雌二醇（EB）和孕酮（P）预处理的去卵巢雌性大鼠进行评估，观察其性接受能力、性主动能力和有节奏的交配行为，然后对其进行急性（30和60mg/kg）或亚慢性（连续10天每天1和10mg/kg）的赫莫尼斯阿魏草提取物处理。在急性（60mg/kg）或亚慢性（1和10mg/kg）给予植物提取物后，观察到大鼠脊柱前凸反应显著降低。同样，与EB+P对照组相比，经赫莫尼斯阿魏草处理的大鼠性主动行为减少。在对照动物和处理动物之间，有节奏的交配行为模式没有差异。目前的结果表明，急性或反复摄入赫莫尼斯阿魏草会特异性损害雌性性行为的接受和主动成分。这种作用可能是提取物在激素预处理的雌性大鼠中产生抗雌激素作用的结果。
