病毒感染的免疫遗传学

Immunogenetics of viral infections.

作者信息

Martin Maureen P, Carrington Mary

机构信息

Basic Research Program, Science Applications International Corporation-Frederick Inc., Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA.

出版信息

Curr Opin Immunol. 2005 Oct;17(5):510-6. doi: 10.1016/j.coi.2005.07.012.

DOI:10.1016/j.coi.2005.07.012

PMID:16084708

Abstract

The HLA class I and II genes encode molecules that lie at the heart of the acquired immune response against infectious diseases. Associations between these polymorphic loci and genetically complex infectious diseases have been historically elusive, in contrast to the more obvious HLA associations with autoimmune diseases. High resolution molecular typing of large, clinically well-defined cohorts has begun to uncover evidence for the influence of HLA diversity on diseases of viral etiology, such as those caused by HIV-1, hepatitis B virus, hepatitis C virus and human papilloma virus. Combinations of HLA and KIR also appear to affect outcome to viral infection, supporting a role for HLA class I diversity in the innate immune response in addition to the acquired immune response.

摘要

HLA I类和II类基因编码的分子是针对传染病的获得性免疫反应的核心。与HLA与自身免疫性疾病的关联更为明显不同，这些多态性位点与遗传复杂的传染病之间的关联一直难以捉摸。对大型、临床定义明确的队列进行高分辨率分子分型，已开始揭示HLA多样性对病毒病因疾病（如由HIV-1、乙型肝炎病毒、丙型肝炎病毒和人乳头瘤病毒引起的疾病）影响的证据。HLA和杀伤细胞免疫球蛋白样受体（KIR）的组合似乎也会影响病毒感染的结果，这支持了HLA I类多样性在固有免疫反应以及获得性免疫反应中的作用。