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HPLC-DAD for analysis of different classes of drugs in plasma.

作者信息

Alabdalla Mahmoud A

机构信息

Department of Chemical Analysis, Forensic Science Laboratory, Amman, Jordan.

出版信息

J Clin Forensic Med. 2005 Dec;12(6):310-5. doi: 10.1016/j.jcfm.2005.05.002. Epub 2005 Aug 5.

DOI:10.1016/j.jcfm.2005.05.002
PMID:16084748
Abstract

A solid-phase extraction technique and HPLC-DAD method for drug screening in plasma were developed. This analytical method extracts and tests a number of drugs of different classes. The method includes; an acidic and basic Solid Phase Extraction (SPE) of plasma with C18 cartridges, a gradient elution of a modified cyano column with acidic buffer/acetonitrile eluent and a photodiode array ultraviolet (UV) detection. The drug screening procedure applied uses retention index and UV spectral data for the identification of compounds, may be appropriate in particular laboratory settings.

摘要

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