Rivera Miguel, Cortés Raquel, Salvador Antonio, Bertomeu Vicente, de Burgos Fernando García, Payá Rafael, Portolés Manuel, Taléns-Visconti Raquel, Martinez-Dolz Luis, Valero Ricardo, Sevilla Begoña, Climent Vicente
Department of Cardiology, Research Center La Fe Hospital, José María Haro, Valencia, Spain.
Eur J Heart Fail. 2005 Dec;7(7):1168-70. doi: 10.1016/j.ejheart.2005.04.003. Epub 2005 Aug 5.
N-terminal pro-brain natriuretic peptide (NT-proBNP) may be useful in the diagnosis of heart failure and ventricular dysfunction. Obesity is an independent cardiovascular risk factor. The purpose of this study was to measure NT-proBNP plasma levels in obese and non-obese subjects with heart failure and to compare levels in subjects with ischaemic and dilated aetiology. In this study, obese subjects had 63% lower NT-proBNP plasma levels than non-obese subjects (p < 0.01). In multivariate analysis, BMI was inversely associated with NT-proBNP plasma levels (p < 0.05) and a 17% decrease in natriuretic peptide levels was attributed to obesity (p < 0.036). When we analyzed data according to the aetiology of heart failure, we found that both groups (ischaemic and dilated) had a 65% decrease in NT-proBNP plasma levels in obese subjects compared to non-obese subjects.
N 端前脑钠肽（NT-proBNP）可能有助于心力衰竭和心室功能障碍的诊断。肥胖是一个独立的心血管危险因素。本研究的目的是测量肥胖和非肥胖心力衰竭患者的血浆 NT-proBNP 水平，并比较缺血性和扩张型病因患者的水平。在本研究中，肥胖受试者的血浆 NT-proBNP 水平比非肥胖受试者低 63%（p < 0.01）。在多变量分析中，体重指数与血浆 NT-proBNP 水平呈负相关（p < 0.05），利钠肽水平降低 17%归因于肥胖（p < 0.036）。当我们根据心力衰竭的病因分析数据时，我们发现两组（缺血性和扩张型）肥胖受试者的血浆 NT-proBNP 水平与非肥胖受试者相比均降低了 65%。
