Green K, MacKeen D L, Slagle T, Cheeks L
Department Ophthalmology, Medical College of Georgia, Augusta 30912-3400.
Ophthalmic Res. 1992;24(2):99-102. doi: 10.1159/000267153.
Isolated rabbit corneas were bathed on their endothelial surfaces with normal Krebs bicarbonate Ringer solution, while the epithelial surfaces were bathed in a basic tear solution containing sodium and potassium. When bathed in basic tear solution alone, corneal swelling occurred at an average of 12 microns/h over a 3-hour period. Corneal swelling occurred at a rate of about 21 microns/h when the epithelial solution was switched from normal basic tear solution to an iso-osmotic K(+)-free basic tear solution. Corneal swelling then slowed, and in the final hour of a 3-hour exposure to K(+)-free tear solution, the corneas deswelled at about 10 microns/h. The data indicate that potassium is a necessary solute for the maintenance of normal corneal thickness. The results suggest that a lacrimal dysfunction that would cause a decrease in the potassium content of tears may influence corneal thickness and also suggest that the inclusion of potassium in artificial tears is important.
将离体兔角膜的内皮表面浸泡在正常的 Krebs 碳酸氢盐林格溶液中，而上皮表面浸泡在含钠和钾的碱性泪液溶液中。仅浸泡在碱性泪液溶液中时，角膜在 3 小时内平均以 12 微米/小时的速度肿胀。当上皮溶液从正常碱性泪液溶液换成等渗无钾碱性泪液溶液时，角膜肿胀速度约为 21 微米/小时。然后角膜肿胀速度减慢，在暴露于无钾泪液溶液的 3 小时的最后一小时，角膜以约 10 微米/小时的速度消肿。数据表明钾是维持正常角膜厚度所必需的溶质。结果表明，导致泪液中钾含量降低的泪腺功能障碍可能会影响角膜厚度，也表明人工泪液中添加钾很重要。
