Zhao Xiao-yi, Liu Hong-wei, Wei Ming-jie
Department of Oral Medicine, Peking University School of Stomatology, Beijing 100081, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Aug 18;37(4):429-32.
To study the relationship of the expressions of new apoptosis-related gene PDCD5 and p53 in oral normal mucosa, oral leukoplakia and oral squamous cell carcinoma.
The expressions of PDCD5 and p53 were observed separately in 17 samples of oral normal mucosa, 60 of oral leukoplakia, and 30 of oral squamous cell carcinoma by Immunohistochemical means.
PDCD5 positive rate in oral normal mucosa was 88.2%, in oral leukoplakia was 63.3%, and in oral squamous cell carcinoma was 30%. P53 positive rate in oral normal mucosa was 0, in oral leukoplakia was 31.7%, and in oral squamous cell carcinoma was 60%. There was a negative relationship between PDCD5 SII and P53 SII in every lesion.
It suggests that both PDCD5 and p53 could be used as molecular markers of carcinogenesis for oral epithelium.
研究新型凋亡相关基因PDCD5和p53在口腔正常黏膜、口腔白斑及口腔鳞状细胞癌中的表达关系。
采用免疫组织化学方法分别观察17例口腔正常黏膜、60例口腔白斑及30例口腔鳞状细胞癌中PDCD5和p53的表达情况。
PDCD5在口腔正常黏膜中的阳性率为88.2%，在口腔白斑中为63.3%，在口腔鳞状细胞癌中为30%。p53在口腔正常黏膜中的阳性率为0，在口腔白斑中为31.7%，在口腔鳞状细胞癌中为60%。在各病变中，PDCD5 SII与P53 SII呈负相关。
提示PDCD5和p53均可作为口腔上皮癌变的分子标志物。
