Olsen A O, Grjibovski A, Magnus P, Tambs K, Harris J R
Department of Dermatology, Ullevaal University Hospital, University of Oslo, Norway.
Br J Dermatol. 2005 Aug;153(2):346-51. doi: 10.1111/j.1365-2133.2005.06613.x.
Psoriasis is a chronic T-cell-mediated immunological skin disease. The occurrence of the disease appears to differ with geography and ethnicity. There is a need for epidemiological data obtained from defined population-based studies, and the sex-specific differences observed in the natural history of the disease require more attention.
To describe the occurrence and risk of psoriasis in Norway by age and sex.
PATIENTS/METHODS: A population-based health survey was conducted in 1998 in Norwegian twins aged 19-31 years. The present study is based upon the self-reported history of psoriasis among the 8045 questionnaire responders.
Altogether, 334 (4.2%) reported a positive history of psoriasis. There were no sex differences in the overall prevalence rates, but significantly higher point-prevalences emerged in females in the teenage-year intervals. A fairly linear increase in incidence rates by every 4-year age-interval peaked at a lower age in females. The mean age at onset was also significantly lower in females (14.8 years) than in males (17.3 years). The absolute risk of developing psoriasis appeared higher for females across the entire age range. However, by the age of 31 the cumulative risks were similar in females and males (0.056 and 0.053, respectively).
In this historical cohort of Norwegian twins, we find a high prevalence of psoriasis in congruence with previously reported data among whites in north-western Europe. We have found sex-specific characteristics in point-prevalences and incidence rates which may contribute to the understanding of the earlier age at onset of the disease in females.
银屑病是一种慢性T细胞介导的免疫性皮肤病。该疾病的发病率似乎因地域和种族而异。需要从基于特定人群的研究中获取流行病学数据，并且在该疾病自然史中观察到的性别差异需要更多关注。
按年龄和性别描述挪威银屑病的发病率及风险。
患者/方法：1998年对19至31岁的挪威双胞胎进行了一项基于人群的健康调查。本研究基于8045名问卷回复者自我报告的银屑病病史。
共有334人（4.2%）报告有银屑病阳性病史。总体患病率无性别差异，但在青少年年龄段，女性的点患病率显著更高。每4年年龄间隔的发病率呈相当线性的上升，在女性中发病年龄较低时达到峰值。女性的平均发病年龄（14.8岁）也显著低于男性（17.3岁）。在整个年龄范围内，女性患银屑病的绝对风险似乎更高。然而，到31岁时，女性和男性的累积风险相似（分别为0.056和0.053）。
在这个挪威双胞胎的历史队列中，我们发现银屑病的患病率很高，与之前在西北欧白人中报告的数据一致。我们发现了点患病率和发病率方面的性别特异性特征，这可能有助于理解女性疾病发病年龄较早的情况。
