Fan Qin, Jia Wei-Hua, Zhang Ru-Hua, Yu Xing-Juan, Chen Li-Zhen, Feng Qi-Sheng, Zeng Yi-Xin
Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
Ai Zheng. 2005 Aug;24(8):915-8.
BACKGROUND & OBJECTIVE: Polymeric immunoglobulin receptor (pIgR) gene plays a central role in immune response, and is closely related to Epstein-Barr virus (EBV) infection. Therefore, it is an ideal candidate gene for research on genetic susceptibility of nasopharyngeal carcinoma (NPC). This study was designed to explore correlation of pIgR gene polymorphisms to genetic susceptibility of NPC.
Four single nucleotide polymorphisms (SNPs) within the exon regions of pIgR were detected by polymerase chain reaction (PCR); pIgR was genotyped in 528 NPC patients and 408 healthy individuals in the Cantonese population to analyze frequencies of its allelic genes.
Differences in frequencies of the 4 SNPs between NPC patients and healthy controls were not significant (P > 0.05). All subjects were categorized into 2 groups by age of 45ûof the subjects in age of < or =45 group, the frequency of minor allele T of SNP C8880T was significantly higher in NPC patients than in healthy controls (7% vs. 4%, P < 0.05). Individuals carried allele T suffered higher risk of NPC (odds ratio=1.84).
SNP C8880T of pIgR is related with NPC susceptibility; pIgR gene may be associated to risk of NPC development.
多聚免疫球蛋白受体（pIgR）基因在免疫反应中起核心作用，且与EB病毒（EBV）感染密切相关。因此，它是鼻咽癌（NPC）遗传易感性研究的理想候选基因。本研究旨在探讨pIgR基因多态性与NPC遗传易感性的相关性。
采用聚合酶链反应（PCR）检测pIgR外显子区域内的4个单核苷酸多态性（SNP）；对528例NPC患者和408例广东人群健康个体的pIgR进行基因分型，分析其等位基因频率。
NPC患者与健康对照之间4个SNP的频率差异无统计学意义（P>0.05）。所有受试者按年龄分为2组，年龄≤45岁组中，NPC患者SNP C8880T次要等位基因T的频率显著高于健康对照（7%对4%，P<0.05）。携带等位基因T的个体患NPC的风险更高（优势比=1.84）。
pIgR的SNP C8880T与NPC易感性相关；pIgR基因可能与NPC发生风险有关。
