眼附属器淋巴增殖性病变中的B细胞表达B细胞趋化因子1（CXCL13）。
B-Cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13).
作者信息
Falkenhagen Katherine M, Braziel Rita M, Fraunfelder Frederick W, Smith Justine R
机构信息
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239-4197, USA.
出版信息
Am J Ophthalmol. 2005 Aug;140(2):335-7. doi: 10.1016/j.ajo.2005.02.026.
PURPOSE
The homeostatic chemokine, B cell attracting chemokine 1 (CXCL13), has been implicated in the pathogenesis of lymphocyte-mediated diseases. We investigated the cellular expression of this chemokine in the spectrum of ocular adnexal lymphoproliferative lesions.
DESIGN
Laboratory investigation.
METHODS
CXCL13 expression in paraffin-embedded adnexal biopsy specimens was determined by indirect immunohistochemistry with antigen retrieval.
RESULTS
In 15 of 16 biopsy specimens, including reactive lymphoid hyperplasia (n = 7), atypical lymphoid hyperplasia (n = 3), and B cell lymphoma (n = 6), CXCL13 was detected. CD20-positive B-cells, as well as dendritic cells and endothelial cells, expressed the chemokine.
CONCLUSIONS
B-cells in ocular adnexal lymphoproliferative lesions demonstrate expression of CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.
目的
稳态趋化因子B细胞趋化因子1（CXCL13）与淋巴细胞介导的疾病发病机制有关。我们研究了这种趋化因子在眼附属器淋巴增殖性病变中的细胞表达情况。
设计
实验室研究。
方法
采用抗原修复间接免疫组化法检测石蜡包埋的附属器活检标本中CXCL13的表达。
结果
在16例活检标本中的15例，包括反应性淋巴增生（n = 7）、非典型淋巴增生（n = 3）和B细胞淋巴瘤（n = 6）中，检测到CXCL13。CD20阳性B细胞以及树突状细胞和内皮细胞表达该趋化因子。
结论
眼附属器淋巴增殖性病变中的B细胞表达CXCL13，这种趋化因子可能参与肿瘤发病机制，是新型治疗的潜在靶点。
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