Cesari Matteo, Kritchevsky Stephen B, Baumgartner Richard N, Atkinson Hal H, Penninx Brenda W H J, Lenchik Leon, Palla Shana L, Ambrosius Walter T, Tracy Russell P, Pahor Marco
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USA.
Am J Clin Nutr. 2005 Aug;82(2):428-34. doi: 10.1093/ajcn.82.2.428.
Age-related body-composition changes are associated with health-related outcomes in elders. This relation may be explained by inflammation and hemostatic abnormalities.
Our objectives were to evaluate the relation between body-composition measures [body mass index (BMI), total fat mass, and appendicular lean mass (aLM)] and C-reactive protein (CRP), interleukin 6 (IL-6), and plasminogen activator inhibitor 1 (PAI-1) and to explore the effect of obesity and sarcopenia on CRP, IL-6, and PAI-1 concentrations.
The data are from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study baseline visit (n = 286; mean age = 66.0 y). Total fat mass and aLM were assessed with a dual-energy X-ray absorptiometry scan. Linear regressions were performed between body-composition measures and CRP, IL-6, or PAI-1 concentrations. The effect of sarcopenia and obesity (defined as the percentage of fat mass) on CRP, IL-6, and PAI-1 concentrations was evaluated with the use of analyses of covariance.
CRP and IL-6 were positively associated with both BMI [beta = 0.027 (P = 0.03) and beta = 0.048 (P < 0.001), respectively] and total fat mass [beta = 0.049 (P < 0.001) and beta = 0.055 (P < 0.001), respectively] and were inversely associated with fat-adjusted aLM [beta = -0.629 (P = 0.002) and beta = -0.467 (P = 0.02), respectively]. PAI-1 was positively associated with both BMI (beta = 0.038, P = 0.005) and total fat mass (beta = 0.032, P = 0.007). No significant interaction was found between either obesity or sarcopenia and CRP, IL-6, and PAI-1 concentrations. Obesity remained significantly associated with high CRP and IL-6 concentrations after adjustments for sarcopenia.
CRP and IL-6 are positively associated with total fat mass and negatively associated with aLM. Obesity-associated inflammation may play an important role in the age-related process that leads to sarcopenia. The relation of inflammation with sarcopenia was not independent of any of the considered obesity indexes.
与年龄相关的身体成分变化与老年人的健康相关结局有关。这种关系可能由炎症和止血异常来解释。
我们的目的是评估身体成分指标[体重指数（BMI）、总脂肪量和四肢瘦体重（aLM）]与C反应蛋白（CRP）、白细胞介素6（IL-6）和纤溶酶原激活物抑制剂1（PAI-1）之间的关系，并探讨肥胖和肌肉减少症对CRP、IL-6和PAI-1浓度的影响。
数据来自血管紧张素转换酶抑制与新型心血管危险因素试验（TRAIN）研究的基线访视（n = 286；平均年龄 = 66.0岁）。通过双能X线吸收法扫描评估总脂肪量和aLM。对身体成分指标与CRP、IL-6或PAI-1浓度进行线性回归分析。使用协方差分析评估肌肉减少症和肥胖（定义为脂肪量百分比）对CRP、IL-6和PAI-1浓度的影响。
CRP和IL-6与BMI[分别为β = 0.027（P = 0.03）和β = 0.048（P < 0.001）]以及总脂肪量[分别为β = 0.049（P < 0.001）和β = 0.055（P < 0.001）]均呈正相关，与脂肪校正后的aLM呈负相关[分别为β = -0.629（P = 0.002）和β = -0.467（P = 0.02）]。PAI-1与BMI（β = 0.038，P = 0.005）和总脂肪量（β = 0.032，P = 0.007）均呈正相关。未发现肥胖或肌肉减少症与CRP、IL-6和PAI-1浓度之间存在显著交互作用。在对肌肉减少症进行校正后，肥胖仍与高CRP和IL-6浓度显著相关。
CRP和IL-6与总脂肪量呈正相关，与aLM呈负相关。肥胖相关炎症可能在导致肌肉减少症的年龄相关过程中起重要作用。炎症与肌肉减少症的关系并非独立于任何所考虑的肥胖指标。
