Zamarrón C, Pichel F, Romero P V
Sleep Unit, Division of Respiratory Medicine, Hospital Clínico Universitario, Santiago de Compostela, Spain.
Physiol Meas. 2005 Oct;26(5):799-810. doi: 10.1088/0967-3334/26/5/017. Epub 2005 Jul 6.
In obstructive sleep apnoea (OSA) cyclical changes in oxygen saturation and heart rate in the period range of 30-120 s are observed. In these patients, we prospectively analyse the coherence of nocturnal SaO(2) and heart rate signals. A sample of 201 clinically suspected of having OSA were studied using nocturnal pulse oximetric and complete polysomnography. Coherence function versus period curves were categorized into three patterns: a positive pattern showing a predominant positive peak value of coherence in the period range of 30-120 s; a negative pattern if the predominant coherence was negative in the same range; and an undetermined pattern if no predominance was detected. One hundred and thirteen patients present a positive coherence pattern; 74.3% of these have OSA. A negative coherence pattern was observed for 28 patients; 85.7% of these have OSA. The remaining 60 patients present an undetermined pattern. Patients with OSA presented significantly higher maximal positive coherence and maximal negative coherence than those without OSA. We conclude that OSA patients present dynamic coordination and interdependence between SaO(2) and heart rate in specific frequencies.
在阻塞性睡眠呼吸暂停（OSA）患者中，观察到氧饱和度和心率在30 - 120秒周期范围内的周期性变化。在这些患者中，我们前瞻性地分析了夜间血氧饱和度（SaO₂）和心率信号的相关性。使用夜间脉搏血氧测定法和完整的多导睡眠图对201例临床怀疑患有OSA的患者进行了研究。相干函数与周期曲线被分为三种模式：一种阳性模式，即在30 - 120秒周期范围内相干性的主要峰值为正值；一种阴性模式，即如果在相同范围内主要相干性为负值；以及一种未确定模式，如果未检测到优势情况。113例患者呈现阳性相干模式；其中74.3%患有OSA。28例患者观察到阴性相干模式；其中85.7%患有OSA。其余60例患者呈现未确定模式。与无OSA的患者相比，OSA患者的最大正相干性和最大负相干性显著更高。我们得出结论，OSA患者在特定频率下，SaO₂和心率之间存在动态协调和相互依存关系。
