Weikert Cornelia, Walter Dietmar, Hoffmann Kurt, Kroke Anja, Bergmann Manuela M, Boeing Heiner
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
Ann Nutr Metab. 2005 Sep-Oct;49(5):312-8. doi: 10.1159/000087335. Epub 2005 Aug 4.
BACKGROUND/AIMS: The role of dietary protein in bone health is controversial. The objective of the present study was to examine the association between protein intake, dietary calcium, and bone structure measured by broadband ultrasound attenuation (BUA).
Our analysis includes 8,178 female study participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) Potsdam Study. Ultrasound bone measurements were performed on the right os calcis, and BUA was determined. Dietary intake was assessed by a standardized food frequency questionnaire. We applied linear regression models to estimate the association between dietary protein and BUA.
After multivariate adjustment, high intake of animal protein was associated with decreased BUA values (beta = -0.03; p = 0.010) whereas high vegetable protein intake was related to an increased BUA (beta = 0.11; p = 0.007). The effect of dietary animal protein on BUA was modified by calcium intake.
High consumption of protein from animal origin may be unfavourable, whereas a higher vegetable protein intake may be beneficial for bone health. Our results strengthen the hypothesis that high calcium intake combined with adequate protein intake based on a high ratio of vegetable to animal protein may be protective against osteoporosis.
背景/目的：膳食蛋白质在骨骼健康中的作用存在争议。本研究的目的是探讨蛋白质摄入量、膳食钙与通过宽带超声衰减（BUA）测量的骨结构之间的关联。
我们的分析纳入了欧洲癌症与营养前瞻性调查（EPIC）波茨坦研究中的8178名女性研究参与者。在右侧跟骨进行超声骨测量，并测定BUA。通过标准化食物频率问卷评估膳食摄入量。我们应用线性回归模型来估计膳食蛋白质与BUA之间的关联。
经过多变量调整后，高动物蛋白摄入量与较低的BUA值相关（β = -0.03；p = 0.010），而高植物蛋白摄入量与较高的BUA相关（β = 0.11；p = 0.007）。膳食动物蛋白对BUA的影响因钙摄入量而改变。
高动物源性蛋白质摄入可能不利，而较高的植物蛋白摄入量可能对骨骼健康有益。我们的结果强化了这样一种假设，即高钙摄入与基于高植物蛋白与动物蛋白比例的充足蛋白质摄入相结合可能预防骨质疏松症。
