Bergelt Corinna, Christensen Jane, Prescott Eva, Grønbaek Morten, Koch Uwe, Johansen Christoffer
Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen.
Cancer. 2005 Sep 15;104(6):1288-95. doi: 10.1002/cncr.21302.
Vital exhaustion, defined as feelings of depression and fatigue, has previously been investigated mainly as a risk factor for cardiovascular disease. The authors investigated the association between depressive feelings and fatigue as covered by the concept of vital exhaustion and the risk for cancer.
The sample consisted of 8527 persons aged 21-94 who had been examined in 1991-1994 within the Copenhagen City Heart Study. For the analysis, the sample was divided into quartiles on the basis of vital exhaustion scores. Cancer cases were ascertained by linkage to the Danish Cancer Registry. The mean length of follow-up was 8.6 years. Regression analyses for etiology-based groups of cancer sites were conducted on the basis of the Cox proportional hazards model, with adjustment for a number of confounding variables.
Cancer was diagnosed in 976 persons (12%) during follow-up. In comparison to those with the lowest scores, persons with the highest vital exhaustion scores had a significantly decreased risk for developing cancer at all sites (hazard ratio [HR], 0.80; 95% confidence interval [CI}, 0.66-0.96), smoking-related cancers (HR, 0.64; 95% CI, 0.46-0.90), and virus and immune-related cancers (HR, 0.51; 95% CI, 0.26-0.99). No significant change in risk was found for cancers related to alcohol consumption or hormones.
The results did not support the hypothesis that symptoms of fatigue and depression, as ascertained in the vital exhaustion index, increased the risk for cancer.
活力耗竭被定义为抑郁和疲劳感，此前主要作为心血管疾病的一个风险因素进行研究。作者研究了活力耗竭概念所涵盖的抑郁情绪与疲劳和癌症风险之间的关联。
样本包括在1991年至1994年哥本哈根市心脏研究中接受检查的8527名年龄在21岁至94岁之间的人。为了进行分析，根据活力耗竭得分将样本分为四分位数。通过与丹麦癌症登记处的关联确定癌症病例。平均随访时间为8.6年。基于病因的癌症部位组的回归分析是在Cox比例风险模型的基础上进行的，并对一些混杂变量进行了调整。
在随访期间，976人（12%）被诊断患有癌症。与得分最低的人相比，活力耗竭得分最高的人在所有部位患癌症的风险显著降低（风险比[HR]，0.80；95%置信区间[CI]，0.66 - 0.96），与吸烟相关的癌症（HR，0.64；95%CI，0.46 - 0.90），以及与病毒和免疫相关的癌症（HR，0.51；95%CI，0.26 - 0.99）。与酒精消费或激素相关的癌症风险未发现显著变化。
结果不支持活力耗竭指数中确定的疲劳和抑郁症状会增加癌症风险这一假设。
Zotero 插件