通过铜催化的[3 + 2]环加成反应实现甲亚胺亚胺的动力学拆分
Kinetic resolutions of azomethine imines via copper-catalyzed [3 + 2] cycloadditions.
作者信息
Suárez Andrés, Downey C Wade, Fu Gregory C
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
J Am Chem Soc. 2005 Aug 17;127(32):11244-5. doi: 10.1021/ja052876h.
An effective method has been developed for the kinetic resolution of racemic azomethine imines via [3 + 2] cycloadditions with alkynes catalyzed by a chiral copper complex. Efficient kinetic resolution is observed for a variety of N1 and C5 substituents on the dipole, thereby furnishing a wide array of useful enantioenriched azomethine imines, which can readily be transformed into monocyclic and bicyclic pyrazolidinones.
已经开发出一种有效的方法，用于通过手性铜配合物催化的与炔烃的[3 + 2]环加成反应对消旋偶氮甲碱亚胺进行动力学拆分。对于偶极子上的各种N1和C5取代基，均观察到有效的动力学拆分，从而提供了各种各样有用的对映体富集的偶氮甲碱亚胺，这些偶氮甲碱亚胺可以很容易地转化为单环和双环吡唑烷酮。
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