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生成的1,2-二氮杂-1,3-二烯与重氮酯的形式[4 + 1]环加成反应：构建含季碳中心二氢吡唑的简便方法。

Formal [4 + 1] cycloaddition of generated 1,2-diaza-1,3-dienes with diazo esters: facile approaches to dihydropyrazoles containing a quaternary center.

作者信息

Chen Bo, Chu Wen-Dao, Liu Quan-Zhong

机构信息

Chemical Synthesis and Pollution Control, Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University No. 1, Shida Road Nanchong 637002 P. R. China

出版信息

RSC Adv. 2019 Jan 11;9(3):1487-1490. doi: 10.1039/c8ra08909d. eCollection 2019 Jan 9.

DOI:10.1039/c8ra08909d
PMID:35518004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9059575/
Abstract

A Cu(ii)/bisoxazoline ligand-promoted formal [4 + 1] cycloaddition of diazo esters with azoalkenes formed has been developed. This strategy provides a potential protocol for the construction of dihydropyrazoles containing a quaternary center with good to excellent yields.

摘要

已开发出一种由铜（II）/双恶唑啉配体促进的重氮酯与生成的偶氮烯烃的形式上的[4 + 1]环加成反应。该策略为构建具有季碳中心的二氢吡唑提供了一种潜在的方法，产率良好至优异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f5/9059575/370e58b82238/c8ra08909d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f5/9059575/daac5124ac1f/c8ra08909d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f5/9059575/2290d06c2698/c8ra08909d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f5/9059575/370e58b82238/c8ra08909d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f5/9059575/daac5124ac1f/c8ra08909d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f5/9059575/2290d06c2698/c8ra08909d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f5/9059575/370e58b82238/c8ra08909d-s3.jpg

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