Mühler A, Clément O, Vexler V, Berthezène Y, Rosenau W, Brasch R C
Department of Radiology, University of California San Francisco 94143-0628.
Radiology. 1992 Jul;184(1):207-13. doi: 10.1148/radiology.184.1.1609081.
Gadolinium (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecandioic acid-disodium salt (EOB-DTPA) ethoxybenzyl is a new hepatobiliary magnetic resonance (MR) contrast agent with dual elimination: 75% through the liver and bile and 25% through the kidneys in normal rats. In this study, Gd-EOB-DTPA was evaluated in a rodent model of metastatic liver disease to measure both relative enhancement and lesion-to-liver contrast. A secondary goal was to compare the relative performance of spin-echo (SE) and short inversion time inversion-recovery (STIR) imaging to demonstrate enhancement with Gd-EOB-DTPA. After administration of 0.1 mmol of Gd-EOB-DTPA per kilogram, liver signal increased (positive enhancement) more than 200% with the use of the SE technique and declined (negative enhancement) by more than 80% with use of the STIR technique. Only minimal enhancement of implanted liver tumor was observed. Unlike the tumor, the gall-bladder and lumen of the duodenum were progressively enhanced over time. The lesion-to-liver contrast increased by approximately 500% with both the SE and STIR techniques after administration of Gd-EOB-DTPA.
钆（4S）-4-（4-乙氧基苄基）-3,6,9-三（羧甲基）-3,6,9-三氮杂十一烷二酸二钠盐（EOB-DTPA）乙氧基苄基是一种新型的具有双重消除途径的肝胆磁共振（MR）造影剂：在正常大鼠中，75%通过肝脏和胆汁消除，25%通过肾脏消除。在本研究中，对Gd-EOB-DTPA在转移性肝病啮齿动物模型中进行评估，以测量相对增强和病变与肝脏的对比度。第二个目标是比较自旋回波（SE）和短反转时间反转恢复（STIR）成像的相对性能，以显示Gd-EOB-DTPA的增强效果。每千克给予0.1 mmol Gd-EOB-DTPA后，使用SE技术时肝脏信号增加（正向增强）超过200%，而使用STIR技术时下降（负向增强）超过80%。仅观察到植入的肝肿瘤有最小程度的增强。与肿瘤不同，胆囊和十二指肠腔随时间逐渐增强。给予Gd-EOB-DTPA后，SE和STIR技术的病变与肝脏对比度均增加了约500%。
