Avizonis V N, Hussey D H, Anderson K M, Jani S K, Berbaum K S
Division of Radiation Oncology, University of Iowa College of Medicine, Iowa City.
Radiology. 1992 Jul;184(1):275-9. doi: 10.1148/radiology.184.1.1609092.
A three-dimensional system for dosimetric calculation of radiation from interstitial brachytherapeutic implants was developed and was compared with conventional dosimetry performed with a commercial two-dimensional system. Software programs written for this study enabled the authors to place radioactive sources in the correct reconstructed anatomic locations, compute the isodose distribution around these sources, and display the isodose curves in their correct relationship to anatomic structures. Eight radiation oncologists evaluated the usefulness of both systems. Verification studies in phantoms and in 20 patients with gold-198 implants in the prostate gland showed that the experimental system was very accurate in volume reconstruction, seed localization, isodose distribution, point-dose calculation, and computation of dose-volume histograms. Although the dose depictions in the two systems matched almost exactly, statistically significant differences existed in interpretation of the dosimetric data generated by both systems. For example, the oncologists consistently believed that the dose to the prostate was lower when the three-dimensional system was used (P less than or equal to .0001).
开发了一种用于间质近距离放射治疗植入物辐射剂量计算的三维系统，并将其与使用商业二维系统进行的传统剂量测定法进行比较。为本研究编写的软件程序使作者能够将放射源放置在正确重建的解剖位置，计算这些源周围的等剂量分布，并以与解剖结构的正确关系显示等剂量曲线。八位放射肿瘤学家评估了这两种系统的实用性。在体模和20例前列腺植入198金的患者中进行的验证研究表明，实验系统在体积重建、种子定位、等剂量分布、点剂量计算和剂量体积直方图计算方面非常准确。尽管两种系统中的剂量描绘几乎完全匹配，但在对两种系统生成的剂量测定数据的解释上存在统计学上的显著差异。例如，肿瘤学家一直认为使用三维系统时前列腺所受剂量较低（P小于或等于0.0001）。
