Ahlawat S K, Richard Locke G, Weaver A L, Farmer S A, Yawn B P, Talley N J
Clinical Enteric Neurosciences and Epidemiological Research, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Aliment Pharmacol Ther. 2005 Aug 1;22(3):251-9. doi: 10.1111/j.1365-2036.2005.02525.x.
Although dyspepsia is common, management patterns in the United States are unknown.
To determine the pattern of dyspepsia evaluation and treatment over 20 years in a population-based cohort, and test the hypothesis that the management was influenced by dyspepsia subgroup and gender.
The validated Bowel Disease Questionnaire was mailed to a random sample of Olmsted County, Minnesota residents (1988-1990). Of the 835 survey respondents, 213 subjects were identified as having dyspepsia according to Rome I Criteria. The medical chart of each dyspeptic subject who had not denied research authorization (n = 206) was reviewed to identify all episodes of care for dyspepsia symptoms 10 years before and 10 years after the date the Bowel Disease Questionnaire was completed. Of these 206 subjects (mean age 47 years, 48% female), 34% had ulcer-like dyspepsia, 32% had dysmotility-like dyspepsia, and 37% had reflux-like dyspepsia.
Nearly half (n = 98, 48%) had episodes of care for dyspepsia symptoms over 20 years. Of these 98 subjects, 49% had upper gastrointestinal endoscopy, 4% motility studies and 12% were tested for Helicobacter pylori. At the first visit of the episode of care closest to Bowel Disease Questionnaire completion, 72% were seen in primary care, 16% in emergency medicine and 2% in gastroenterology. In addition, 13% were referred to gastroenterology clinic within this episode. During the study period, 70% were given an 'acid' diagnosis, 7% a 'motility' diagnosis and 54% a 'functional' diagnosis; 78% received acid suppression agents (28% proton pump inhibitors), 18% psychotropic agents and 7% prokinetic agents. No significant association was found between gender and test usage, specialty referral or type of treatment, although women were three times less likely to receive proton pump inhibitors (odds ratio 3.3, 95% CI: 1.2-9.1). Symptom severity, frequency and pattern were risk factors for health care seeking in dyspepsia.
Delivery of care for dyspepsia was similar among dyspepsia subgroups and in men and women.
尽管消化不良很常见,但美国的管理模式尚不清楚。
确定基于人群队列中20年来消化不良评估和治疗的模式,并检验管理受消化不良亚组和性别的影响这一假设。
将经过验证的肠道疾病问卷邮寄给明尼苏达州奥尔姆斯特德县居民的随机样本(1988 - 1990年)。在835名调查受访者中,根据罗马I标准,有213名受试者被确定患有消化不良。对未拒绝研究授权的每位消化不良受试者(n = 206)的病历进行审查,以确定在完成肠道疾病问卷日期之前10年和之后10年因消化不良症状而接受治疗的所有情况。在这206名受试者(平均年龄47岁,48%为女性)中,34%患有溃疡样消化不良,32%患有动力障碍样消化不良,37%患有反流样消化不良。
近一半(n = 98,48%)的受试者在20年中有因消化不良症状而接受治疗的情况。在这98名受试者中,49%接受了上消化道内镜检查,4%进行了动力研究,12%检测了幽门螺杆菌。在最接近完成肠道疾病问卷的那次治疗就诊时,72%在初级保健机构就诊,16%在急诊科就诊,2%在胃肠病科就诊。此外,在这次治疗期间,13%被转诊至胃肠病科诊所。在研究期间,70%被诊断为“酸性”疾病,7%被诊断为“动力”疾病,54%被诊断为“功能性”疾病;78%接受了抑酸剂(28%为质子泵抑制剂),