Neely Michael, Kovacs Andrea
Division of Pediatric Infectious Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90041, USA.
Curr HIV/AIDS Rep. 2004 Jun;1(2):97-104. doi: 10.1007/s11904-004-0014-y.
There have been tremendous advances in the prevention of maternal-to-child transmission of HIV and treatment of HIV-infected children and adolescents. Although multiple classes of anti-HIV drugs are available that can control viral replication and stabilize immune function when used in combination, patients and their providers must also manage complex and frequently toxic regimens. This article updates our original report that summarizes official National Institutes of Health guidelines for the prevention of perinatal HIV infection and the management of pediatric and adolescent HIV infection and provides the most current updates on indications for therapy, recommended first-line therapy, criteria for changing therapy, salvage therapy, novel management strategies, and a comprehensive summary of available antiretroviral agents.
在预防艾滋病毒母婴传播以及治疗感染艾滋病毒的儿童和青少年方面已经取得了巨大进展。尽管有多种抗艾滋病毒药物可供使用，联合使用时可以控制病毒复制并稳定免疫功能，但患者及其医护人员还必须应对复杂且往往有毒性的治疗方案。本文更新了我们最初的报告，该报告总结了美国国立卫生研究院关于预防围产期艾滋病毒感染以及治疗儿童和青少年艾滋病毒感染的官方指南，并提供了治疗指征、推荐的一线治疗、更改治疗的标准、挽救治疗、新型管理策略的最新更新，以及可用抗逆转录病毒药物的全面总结。
