Kiser Jennifer J, Anderson Peter L, Gerber John G
Division of Clinical Pharmacology, University of Colorado Health Science Center, Denver, CO 80262, USA.
Curr HIV/AIDS Rep. 2005 Jun;2(2):61-7. doi: 10.1007/s11904-005-0020-8.
Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstrating that prospectively altering ARV doses based on TDM leads to virologic success and increased tolerability are needed. Nevertheless, there are specific clinical instances where this experimental intervention should be considered to potentially reduce toxicity and improve therapeutic outcomes.
治疗药物监测（TDM）是一个通过反复测量血浆药物浓度来指导患者给药方案的过程。抗逆转录病毒药物（ARV）的TDM面临的一个巨大挑战是，浓度目标可能是动态变化的。需要精心设计的前瞻性研究来证明基于TDM前瞻性地调整ARV剂量可导致病毒学成功并提高耐受性。然而，在某些特定的临床情况下，应考虑这种实验性干预，以潜在地降低毒性并改善治疗效果。
