Debusscher L
Unité d'Hématologie, Institut Jules Bordet, Bruxelles.
Rev Med Brux. 1992 May;13(5):160-6.
For severe aplastic anemia and several malignant hemopathies allogeneic bone marrow transplantation is the only treatment with curative potential. This is the case for chronic myelogenous leukemia, the myelodysplastic syndromes and probably multiple myeloma and chronic lymphocytic leukemia. It seems also the best therapeutic option for young adults who suffer from acute leukemia and for whom an adequate family donor is available. We review here the main complications of the procedure. Their better knowledge and the way to prevent and to treat them has decreased the mortality and morbidity of this treatment which is mostly successful when applied on patients in the early phase of their disease. Recently, the availability of HLA typed registered volunteers has extended the applicability of allogeneic bone marrow transplantation for those patients who lack adequate familial donors.
对于重型再生障碍性贫血和几种恶性血液病，异基因骨髓移植是唯一具有治愈潜力的治疗方法。慢性粒细胞白血病、骨髓增生异常综合征以及可能的多发性骨髓瘤和慢性淋巴细胞白血病均属这种情况。对于患有急性白血病且有合适家庭供者的年轻成年人而言，这似乎也是最佳的治疗选择。我们在此回顾该手术的主要并发症。对它们更深入的了解以及预防和治疗方法已降低了这种治疗的死亡率和发病率，该治疗在疾病早期应用于患者时大多是成功的。最近，人类白细胞抗原（HLA）分型登记志愿者的出现，扩大了异基因骨髓移植对那些缺乏合适家庭供者患者的适用性。
