Erdös G, Kunde M, Tzanova I, Werner C
Klinik für Anästhesiologie, Johannes Gutenberg-Universität, Langenbeckstrasse 1, 55131 Mainz.
Anaesthesist. 2005 Dec;54(12):1215-28. doi: 10.1007/s00101-005-0895-1.
The perioperative management of patients with mediastinal masses is a special clinical challenge in our field. Even though regional anaesthesia is normally the first choice, in some cases it is not feasible due to the method of operation. In these cases general anaesthesia is the second option but can lead to respiratory and haemodynamic decompensation due to tumor-associated compression syndrome (mediastinal mass syndrome). The appropriate treatment begins with the preoperative risk classification on the basis of clinical and radiological findings. In addition to anamnesis, chest radiograph, and CT, dynamical methods (e.g. pneumotachography and echocardiography) should be applied to verify possible intraoperative compression syndromes. The induction of general anaesthesia is to be realized in awake-fiberoptic intubation with introduction of the tube via nasal route while maintaining the spontaneous breathing of the patient. The anaesthesia continues with short effective agents applied inhalative or iv. If possible from the point of operation, agents of muscle relaxation are not to be applied. If the anaesthesia risk is classified as uncertain or unsafe, depending on the location of tumor compression (tracheobronchial tree, pulmonary artery, superior vena cava), alternative techniques of securing the respiratory tract (different tubes, rigid bronchoscope) and cardiopulmonary bypass with extracorporal oxygen supply are prepared. For patients with severe clinical symptoms and extensive mediastinal mass, the preoperative cannulation of femoral vessels is also recommended. In addition to fulfilling technical and personnel requirements, an interdisciplinary cooperation of participating fields is the most important prerequisite for the optimal treatment of patients.
纵隔肿物患者的围手术期管理是我们这个领域一项特殊的临床挑战。尽管区域麻醉通常是首选,但在某些情况下,由于手术方式的原因,它并不可行。在这些情况下,全身麻醉是第二选择,但可能会因肿瘤相关压迫综合征(纵隔肿物综合征)导致呼吸和血流动力学失代偿。恰当的治疗始于根据临床和影像学检查结果进行术前风险分级。除了病史、胸部X光片和CT外,还应采用动态检查方法(如呼吸流速描记法和超声心动图)来验证可能的术中压迫综合征。全身麻醉诱导应采用清醒纤维支气管镜经鼻插管,同时保持患者自主呼吸。麻醉持续过程中采用吸入或静脉注射短效有效药物。从手术角度看,尽可能不使用肌肉松弛剂。如果麻醉风险被判定为不确定或不安全,根据肿瘤压迫的部位(气管支气管树、肺动脉、上腔静脉),要准备好替代的呼吸道保障技术(不同型号的气管导管、硬质支气管镜)以及体外供氧的体外循环。对于临床症状严重且纵隔肿物范围广泛的患者,术前建议进行股血管插管。除满足技术和人员要求外,各参与领域的多学科合作是患者获得最佳治疗的最重要前提。