Nybaek Hanne, Olsen A G, Karlsmark T, Jemec G B E
Division of Dermatology, Department of Medicine, Roskilde Hospital, Roskilde, Denmark.
J Cutan Med Surg. 2004 Jul-Aug;8(4):220-3. doi: 10.1007/s10227-004-0105-9.
Pyoderma gangrenosum (PG) is an uncommon condition. Literature on the management of peristomal PG (PPG) is sparse. In the absence of randomized controlled trials the reporting of case series is potentially helpful to the management of this uncommon disease.
In this study we report our experience with topical corticosteroid therapy for 14 consecutive cases of PPG.
A clinical diagnosis PPG was made by a trained dermatologist using the appropriate investigations where necessary.
The majority of the cases presented were managed with simple topical corticosteroids, occasionally in combination with a change of dressing. In 8/14 (57%) cases ulcer resolution was achieved within 3 months with topical treatment alone or topical treatment plus a change of dressing to a silicone-based product applied directly to the wound under the normal base plate of the stoma bag.
Our experience suggests that a significant proportion of PPG can be managed by topical treatment alone. The simple topical treatment allows the patient to continue use of stoma care products while minimizing the potential for side effects.
坏疽性脓皮病（PG）是一种罕见疾病。关于造口周围坏疽性脓皮病（PPG）治疗的文献稀少。在缺乏随机对照试验的情况下，病例系列报告可能有助于这种罕见疾病的治疗。
在本研究中，我们报告了连续14例PPG患者使用局部皮质类固醇治疗的经验。
由训练有素的皮肤科医生在必要时进行适当检查后做出PPG的临床诊断。
大多数病例采用单纯局部皮质类固醇治疗，偶尔联合更换敷料。在8/14（57%）的病例中，仅通过局部治疗或局部治疗加更换敷料（在造口袋正常底盘下直接将基于硅酮的产品应用于伤口），溃疡在3个月内愈合。
我们的经验表明，相当一部分PPG仅通过局部治疗即可控制。这种简单的局部治疗使患者能够继续使用造口护理产品，同时将副作用的可能性降至最低。
