Hsu Ron-Bin
Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China.
Infect Control Hosp Epidemiol. 2005 Jul;26(7):654-7. doi: 10.1086/502597.
Nosocomial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are increasing. Only a few studies of MRSA infective endocarditis have been conducted, and none have reported its risk factors. We sought to determine the host-related risk factors for infective endocarditis in patients with nosocomial MRSA bacteremia.
A 2,000-bed, university-affiliated, tertiary-care hospital.
Thirty-one patients with nosocomial MRSA infective endocarditis between October 1996 and May 2003.
A retrospective chart review was conducted. Data were compared with those from a control group of patients with nosocomial MRSA bacteremia. Logistic regression was used to identify independent risk factors for nosocomial infective endocarditis.
Compared with patients who had nosocomial MRSA bacteremia and no infective endocarditis, patients who had infective endocarditis had a higher incidence of chronic liver disease and a lower incidence of immunodeficiency. The risk of developing infective endocarditis was approximately 10% for patients with nosocomial MRSA bacteremia.
Patients with MRSA bacteremia and underlying chronic liver disease were prone to infective endocarditis.
耐甲氧西林金黄色葡萄球菌（MRSA）引起的医院感染正在增加。关于MRSA感染性心内膜炎的研究较少，且尚无关于其危险因素的报道。我们试图确定医院获得性MRSA菌血症患者感染性心内膜炎的宿主相关危险因素。
一家拥有2000张床位的大学附属医院，三级医疗机构。
1996年10月至2003年5月期间31例医院获得性MRSA感染性心内膜炎患者。
进行回顾性病历审查。将数据与医院获得性MRSA菌血症患者对照组的数据进行比较。采用逻辑回归分析确定医院获得性感染性心内膜炎的独立危险因素。
与医院获得性MRSA菌血症且无感染性心内膜炎的患者相比，感染性心内膜炎患者的慢性肝病发病率较高，免疫缺陷发病率较低。医院获得性MRSA菌血症患者发生感染性心内膜炎的风险约为10%。
患有MRSA菌血症和潜在慢性肝病的患者易患感染性心内膜炎。
