奎宁定的亚磷酸酯衍生物对环状内消旋-1,3-二醇和1,4-二醇的催化不对称去对称化反应
Catalytic asymmetric desymmetrization of cyclic meso-1,3- and 1,4-diols by a phosphinite derivative of quinidine.
作者信息
Mizuta Shinya, Tsuzuki Takeo, Fujimoto Tetsuya, Yamamoto Iwao
机构信息
Department of Functional Polymer Science, Shinshu University, Tokida Ueda 386-8567, Japan.
出版信息
Org Lett. 2005 Aug 18;7(17):3633-5. doi: 10.1021/ol051129m.
PMID:16092837
Abstract
Asymmetric monobenzoylation reactions of cyclic meso-1,3- and 1,4-diols were catalyzed by a phosphinite derivative of quinidine to afford the corresponding monobenzoylated diol with good yield and enantioselectivity. [reaction: see text]
摘要
奎尼丁的次膦酸酯衍生物催化环状内消旋-1,3-二醇和1,4-二醇的不对称单苯甲酰化反应，以良好的产率和对映选择性得到相应的单苯甲酰化二醇。[反应：见正文]
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