Tominaga Masahide, Masu Hyuma, Katagiri Kosuke, Kato Takako, Azumaya Isao
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan.
Org Lett. 2005 Aug 18;7(17):3785-7. doi: 10.1021/ol051477o.
A triple helicate, having a macrocyclic aromatic amide structure, was synthesized in high yield because of a preorganized component of the tertiary benzenetrianilide moieties in a propeller-like syn conformation at both ends. The helicity was derived from tilted T-shaped aromatic-aromatic (CH-pi) interactions between each of the N-phenyl rings. [structure: see text]
