Escobar-Chávez José Juan, Quintanar-Guerrero David, Ganem-Quintanar Adriana
División de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, Mexico.
Drug Dev Ind Pharm. 2005 May;31(4-5):447-54. doi: 10.1080/03639040500214662.
The objective of this study was to determine the penetration of sodium naproxen, formulated in Pluronic F-127 (PF-127) gels containing Azone and Transcutol as penetration enhancers, through human skin in vivo. It was found that the combination of Azone and Transcutol in PF-127 gels enhanced sodium naproxen penetration, with enhancement ratios of up to two fold compared with the formulation containing only Transcutol. These results were confirmed by TEWL and ATR-FTIR spectroscopy, suggesting a synergic action for Azone and Transcutol. Because of the thermo-reversible behavior of Pluronic gels, the influence of the components added to the gel formulations on viscosity, as a function of temperature, was also studied.
本研究的目的是确定在含有氮酮（Azone）和二甲基亚砜（Transcutol）作为渗透促进剂的泊洛沙姆F-127（PF-127）凝胶中配制的萘普生钠在体内透过人体皮肤的情况。研究发现，在PF-127凝胶中氮酮和二甲基亚砜的组合增强了萘普生钠的渗透，与仅含有二甲基亚砜的制剂相比，增强率高达两倍。经皮水分流失（TEWL）和衰减全反射傅里叶变换红外光谱（ATR-FTIR）证实了这些结果，表明氮酮和二甲基亚砜具有协同作用。由于泊洛沙姆凝胶的热可逆行为，还研究了添加到凝胶制剂中的成分对粘度随温度变化的影响。
