Paviour D C, Winterburn D, Simmonds S, Burgess G, Wilkinson L, Fox N C, Lees A J, Jahanshahi M
The Sara Koe PSP Research Centre, Institute of Neurology, London, UK.
Neurocase. 2005 Aug;11(4):274-82. doi: 10.1080/13554790590962933.
The frontal assessment battery (FAB) is a bedside test of executive function. It takes less than 10 minutes to administer and a low score indicates executive dysfunction. To determine whether the FAB could detect the more severe subcortical dementia that is a feature of PSP and differentiate it from other bradykinetic rigid syndromes, we studied 17 patients with progressive supranuclear palsy (PSP); 11 with multiple system atrophy (MSA) and 12 with Parkinson's disease (PD). We compared FAB scores with the results of more detailed tests of executive and general cognitive function.FAB scores were significantly lower in PSP than in MSA or PD (p=0.02 and p<0.001) and were also found to be significantly lower in MSA than in PD (p=0.047). We divided the study group into those with an FAB score <15 and those with an FAB score>/=5, regardless of the clinical diagnosis. While 82% of the PSP group had FAB scores of <15, such scores were recorded in only 36% of the MSA and 8% of the PD groups. The lexical fluency and motor series subscores of the FAB discriminated 70% of the PSP, MSA and PD patients. The FAB scores correlated with tests of executive function, as well as with scores on the Mattis Dementia Rating Scale, the Mini Mental State Examination and other tests of general cognitive function. A stepwise regression analysis revealed that across the groups, among the variables that correlated with FAB scores, alternating semantic fluency accounted for 80% of FAB variance.These results suggest that the FAB is a valid and easily applicable bedside test to discriminate executive dysfunction in these three frequently confused bradykinetic rigid syndromes.
额叶评估量表（FAB）是一种执行功能的床边测试。实施该测试耗时不到10分钟，低分表明存在执行功能障碍。为了确定FAB能否检测出进行性核上性麻痹（PSP）所特有的更严重的皮质下痴呆，并将其与其他运动迟缓僵硬综合征相区分，我们研究了17例进行性核上性麻痹（PSP）患者、11例多系统萎缩（MSA）患者和12例帕金森病（PD）患者。我们将FAB评分与更详细的执行和一般认知功能测试结果进行了比较。PSP患者的FAB评分显著低于MSA或PD患者（p = 0.02和p < 0.001），并且还发现MSA患者的FAB评分显著低于PD患者（p = 0.047）。我们将研究组分为FAB评分<15分和FAB评分≥15分的两组，而不考虑临床诊断。虽然PSP组中82%的患者FAB评分<15分，但MSA组中只有36%的患者以及PD组中只有8%的患者有如此评分。FAB的词汇流畅性和运动序列子评分能够区分70%的PSP、MSA和PD患者。FAB评分与执行功能测试以及马蒂斯痴呆评定量表、简易精神状态检查和其他一般认知功能测试的评分相关。逐步回归分析显示，在所有组中,与FAB评分相关的变量中，交替语义流畅性占FAB方差的80%。这些结果表明，FAB是一种有效且易于应用的床边测试，可用于鉴别这三种经常混淆的运动迟缓僵硬综合征中的执行功能障碍。
