Versleijen M W J, Naber A H J, Riksen N P, Wanten G J, Debruyne F M J
Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Neth J Med. 2005 Jul-Aug;63(7):275-7.
We report a female patient who repeatedly developed pancreatitis after trimethoprim-sulfamethoxazole (TMP/SMX) use. During childhood she had undergone an ureterosigmoidostomy after which she had been on TMP/SMX 480 mg daily as prophylaxis for pyelonephritis for many years. The patient presented with abdominal pain caused by acute pancreatitis. No other cause, except for TMP/SMX use, could be identified. A causal relationship was confirmed by relapse of the pancreatitis after rechallenge. Our case is unique in demonstrating that acute pancreatitis related to the use of TMP/SMX may occur even after long-term treatment. We advise that the medication is discontinued immediately if a causal relationship with pancreatitis is suspected.
我们报告了一名女性患者，她在使用甲氧苄啶-磺胺甲恶唑（TMP/SMX）后反复发生胰腺炎。童年时期，她接受了输尿管乙状结肠吻合术，此后多年一直每日服用480毫克TMP/SMX预防肾盂肾炎。该患者因急性胰腺炎出现腹痛。除使用TMP/SMX外，未发现其他病因。再次用药后胰腺炎复发证实了因果关系。我们的病例独特之处在于表明，即使经过长期治疗，与使用TMP/SMX相关的急性胰腺炎仍可能发生。我们建议，如果怀疑与胰腺炎存在因果关系，应立即停用该药物。
