转座元件向宿主基因组捐赠谱系特异性调控序列。
Transposable elements donate lineage-specific regulatory sequences to host genomes.
作者信息
Mariño-Ramírez L, Lewis K C, Landsman D, Jordan I K
机构信息
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA.
出版信息
Cytogenet Genome Res. 2005;110(1-4):333-41. doi: 10.1159/000084965.
Abstract
The evolutionary implications of transposable element (TE) influences on gene regulation are explored here. An historical perspective is presented to underscore the importance of TE influences on gene regulation with respect to both the discovery of TEs and the early conceptualization of their potential impact on host genome evolution. Evidence that points to a role for TEs in host gene regulation is reviewed, and comparisons between genome sequences are used to demonstrate the fact that TEs are particularly lineage-specific components of their host genomes. Consistent with these two properties of TEs, regulatory effects and evolutionary specificity, human-mouse genome wide sequence comparisons reveal that the regulatory sequences that are contributed by TEs are exceptionally lineage specific. This suggests a particular mechanism by which TEs may drive the diversification of gene regulation between evolutionary lineages.
摘要
本文探讨了转座元件（TE）对基因调控的进化影响。文中呈现了一个历史视角，以强调TE对基因调控的影响在TE的发现以及其对宿主基因组进化潜在影响的早期概念化方面的重要性。回顾了表明TE在宿主基因调控中起作用的证据，并利用基因组序列之间的比较来证明TE是其宿主基因组中特别具有谱系特异性的成分这一事实。与TE的这两个特性，即调控效应和进化特异性相一致，人类与小鼠全基因组序列比较显示，由TE贡献的调控序列具有异常的谱系特异性。这提示了一种特定机制，通过该机制TE可能推动进化谱系间基因调控的多样化。
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