Tanaka Satoshi, Kobayashi Ikuo, Sagiuchi Takao, Takanashi Junko, Iwamoto Kazuhisa, Sato Sumito, Fujii Kiyotaka
Department of Neurosurgery and Clinical Laboratory, The Kitasato Institute Medical Center Hospital, Kitamoto, and Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Japan.
J Clin Neurophysiol. 2005 Aug;22(4):271-4. doi: 10.1097/01.wnp.0000166169.25564.f4.
It is often difficult to evaluate the results of transcranial motor-evoked potential (TCMEP) monitoring in patients under general anesthesia because these results are strongly affected by anesthetics and muscle relaxants. To exclude effects of muscle relaxants on TCMEP, compound muscle action potential (CMAP) by supramaximum stimulation of the median nerve immediately after transcranial stimulation (300 to 600 V) was recorded in 70 neurosurgical operations. A relative amplitude index (RAI) was defined as the amplitude of TCMEP after the operative procedure divided by the amplitude of TCMEP before the operative procedure. The RAI was calculated and was compensated by the amplitude of CMAP in 141 limbs. In 12 limbs of 7 patients with postoperatively progressed motor paresis, the compensated RAI was less than 0.2. The compensated RAI in all other 129 limbs of 63 patients without postoperative motor palsy was more than 0.2. These results suggest that compensation of TCMEP monitoring by CMAP is an easy and accurate method for removing the effects of muscle relaxants in TCMEP.
