Kagawa M, Yamamoto A, Ogawa K, Shirai T, Fukushima S
1st Department of Pathology, Nagoya City University Medical School, Japan.
Toxicol Lett. 1992 Jun;61(1):21-6. doi: 10.1016/0378-4274(92)90059-s.
The correlation between urolithiasis due to uracil administration and epithelial proliferation in the urinary bladder was investigated in male F344 rats. Animals, 6 weeks old at the start, which ingested 3% uracil alone in the diet for 4 weeks developed urolithiasis and papillomatosis of the urinary bladder, whereas addition of NaCl, particularly at high concentration (10%), to the 3% uracil in the diet blocked production of both. In contrast, NaHCO3 was without influence on either calculi or proliferative changes. These results indicate that uracil-induced epithelial proliferation is due to direct mechanical irritation by calculi, and not to any chemical stimulus presented by uracil itself.
在雄性F344大鼠中研究了给予尿嘧啶导致的尿路结石与膀胱上皮增殖之间的相关性。实验开始时6周龄的动物，在饮食中单独摄入3%尿嘧啶4周后，出现了尿路结石和膀胱乳头状瘤，而在饮食中3%尿嘧啶里添加NaCl，特别是高浓度（10%）的NaCl，可抑制两者的形成。相比之下，NaHCO₃对结石或增殖性变化均无影响。这些结果表明，尿嘧啶诱导的上皮增殖是由结石直接机械刺激所致，而非尿嘧啶本身呈现的任何化学刺激。
